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KMID : 1101320040360020269
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Korean Journal of Clinical Laboratory Science
2004 Volume.36 No. 2 p.269 ~ p.273
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The Effect of Saliva in Squamous Cell Carcinoma(SCC) and Thyroid Function Test with Radioimmunoassay
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Cho Man-Ick
Moon Ki-Choon
Kim Hea-Suk
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Abstract
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Squamous cell carcinoma(SCC) associated antigen is a subfraction of TA-4, a tumor-associated antigen first described by Kato and Torigoe in 1977. TA-4, obtained from squamous cell carcinoma cancer tissue of the uterine cervix, has been characterized as a glycoprotein with a molecular weight of approximately 45,000 daltons. SCC antigen has been studied in other squamous cell malignancies including lung, esophagus, head and neck, anal canal, and skin. SCC antigen is shed naturally through sweat, saliva and other body fluids. Contamination of specimens, tray, bead dispenser or other accessories with sweat, saliva or aerosols can cause falsely elevated values. To reduce the possibility of contamination, gloves should be worn in all phases of assay preparation, and when handling specimens, accessories or reagents that will be used in SCC and Thyroid function test(TFT).
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KEYWORD
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SCC antigen, TA-4, Saliva, Contamination, TFT
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